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Tretinoin reliably produces what dermatologists call retinoid dermatitis or the 'retinization' period during the first two to eight weeks: redness, flaking, dryness, stinging, and sometimes a temporary flare of breakouts

Moreover, UV radiation can activate the proopiomelanocortin (POMC) gene and thereby enhance the production of alpha-melanocyte stimulating hormone (-MSH) and adrenocorticotropic hormone (ACTH) which can lead to increased PKA and melanogenesis (Im et al., 2002)

Some sources focus on injectable protocols

The 6.6-percentage-point cagrilintide layer-on effect over semaglutide alone is the closest analog for what cagrilintide adds here